Structure of PDB 7ujq Chain A

Receptor sequence
>7ujqA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISHR
3D structure
PDB7ujq CaMKII binds both substrates and activators at the active site.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K56 E96 F98 E99 N135 K137 E139 L159 F173 A174 G175 P177 G178 Y210 P211 W214 Q218 K50 E90 F92 E93 N129 K131 E133 L153 F167 A168 G169 P171 G172 Y204 P205 W208 Q212
BS02 peptide A G22 A23 N45 G16 A17 N39
BS03 UZD A A40 F89 L91 V92 D156 A34 F83 L85 V86 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ujq, PDBe:7ujq, PDBj:7ujq
PDBsum7ujq
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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