Structure of PDB 7uix Chain A

Receptor sequence
>7uixA (length=577) Species: 562 (Escherichia coli) [Search protein sequence]
FTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKT
AIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFKALL
KQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIGS
TTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDV
RYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRKKTV
NVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEALT
EAIKMARAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDM
SEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEKAHP
DVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIGLIH
QDNSTDAMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVELQV
QLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANELL
FGSLVDGGQVTVALDKEKNELTYGFQS
3D structure
PDB7uix AAA+ protease-adaptor structures reveal altered conformations and ring specialization.
ChainA
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G217 G219 T221 I357 G46 G48 T50 I186
BS02 ADP A G498 G500 K664 R702 G327 G329 K493 R531
BS03 ADP A R335 R339 R164 R168
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0006979 response to oxidative stress
GO:0034605 cellular response to heat
GO:0043335 protein unfolding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009368 endopeptidase Clp complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7uix, PDBe:7uix, PDBj:7uix
PDBsum7uix
PubMed36329286
UniProtP0ABH9|CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA (Gene Name=clpA)

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