Structure of PDB 7uir Chain A

Receptor sequence
>7uirA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISHR
3D structure
PDB7uir CaMKII binds both substrates and activators at the active site.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F98 E99 E105 K137 E139 G175 T176 P177 G178 I205 V208 G209 Y210 W214 P233 E236 F92 E93 E99 K131 E133 G169 T170 P171 G172 I199 V202 G203 Y204 W208 P227 E230
BS02 ATP A G22 S25 A40 K42 V92 E96 L142 D156 G16 S19 A34 K36 V86 E90 L136 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7uir, PDBe:7uir, PDBj:7uir
PDBsum7uir
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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