Structure of PDB 7uiq Chain A

Receptor sequence
>7uiqA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISHR
3D structure
PDB7uiq CaMKII binds both substrates and activators at the active site.
ChainA
Resolution3.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E96 F98 E99 E105 Y106 E139 G175 T176 V208 G209 Y210 W214 E216 P233 E236 E90 F92 E93 E99 Y100 E133 G169 T170 V202 G203 Y204 W208 E210 P227 E230
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7uiq, PDBe:7uiq, PDBj:7uiq
PDBsum7uiq
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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