Structure of PDB 7uih Chain A

Receptor sequence
>7uihA (length=574) Species: 9606 (Homo sapiens) [Search protein sequence]
RFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSED
VEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYSARMNLASSFV
NGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLT
QIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDFVLHNSNTM
RLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAV
GSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAIL
AALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSK
FSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMV
RLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILG
KSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQQTHTTPVLLAHGER
AELATEEFLPVTPILEGFVILRKN
3D structure
PDB7uih Targeted degradation via direct 26S proteasome recruitment.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R680 Y681 R687 K712 R368 Y369 R375 K400
BS02 peptide A H677 Y681 E683 H365 Y369 E371
BS03 peptide A A464 L465 A187 L188
BS04 peptide A D394 N396 L426 T427 D430 K431 Y434 D117 N119 L149 T150 D153 K154 Y157
External links
PDB RCSB:7uih, PDBe:7uih, PDBj:7uih
PDBsum7uih
PubMed36577875
UniProtQ13200|PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2 (Gene Name=PSMD2)

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