Structure of PDB 7uhy Chain A

Receptor sequence
>7uhyA (length=771) Species: 9606 (Homo sapiens) [Search protein sequence]
KPDILWAPHHVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLL
SINSDTPYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLI
GKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSTKPLY
ELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQG
VTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTR
TGLLATLTRDSNIIRLYDMQHTTIIERSVQPCDNYIASFAWHPTSQNRMI
VVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECTEEENDNSLEKD
IATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTED
MDQKSLVYAGIKSIVKSSLGMVESSRHNWSIQNLNEERILALQLCGWIKK
GTDVDVGPFLNSLVQEGEWERAAAVALFNLDIRRAIQILNEGASSELNLN
VVAMALSGYTDEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSETGSYDGV
LYENKVAVRDRVAFACKFLSDTQLNRYIEKLTNEMKEAGNLEGILLTGLT
KDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLD
AWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSKVTSCPGC
RKPLPRCALCLINMGTPVSSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSW
FRDHAECPVSACTCKCMQLDT
3D structure
PDB7uhy Structure of the nutrient-sensing hub GATOR2.
ChainA
Resolution3.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C737 C740 C775 C682 C685 C697
BS02 ZN A C785 H835 H838 C707 H743 H746
BS03 ZN A C827 C830 C856 C735 C738 C764
BS04 ZN A C830 H832 C849 C738 H740 C757
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0031503 protein-containing complex localization
GO:0031669 cellular response to nutrient levels
GO:0032289 central nervous system myelin formation
GO:0034198 cellular response to amino acid starvation
GO:0048709 oligodendrocyte differentiation
GO:0070444 oligodendrocyte progenitor proliferation
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0030054 cell junction
GO:0061700 GATOR2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uhy, PDBe:7uhy, PDBj:7uhy
PDBsum7uhy
PubMed35831510
UniProtQ9NXC5|MIOS_HUMAN GATOR2 complex protein MIOS (Gene Name=MIOS)

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