Structure of PDB 7uhp Chain A

Receptor sequence
>7uhpA (length=264) Species: 522373 (Stenotrophomonas maltophilia K279a) [Search protein sequence]
APLPQLRAYTVDASWLQPMAPLQVADHTWQIGTEDLTALLVQTAEGAVLL
DGGMPQMAGHLLDNMKLRGVAPQDLRLILLSHAHADHAGPVAELKRRTGA
HVAANAETAVLLARGGSNDLHFGDGITYPPASADRIIMDGEVVTVGGIAF
TAHFMPGHTPGSTAWTWTDTRDGKPVRIAYADSLSAPGYQLKGNPRYPRL
IEDYKRSFATVRALPCDLLLTPHPGASNWNYAVGSKASAEALTCNAYADA
AEKKFDAQLARETA
3D structure
PDB7uhp Time-resolved beta-lactam cleavage by L1 metallo-beta-lactamase.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H105 H107 H181 H82 H84 H158
BS02 ZN A D109 H110 H246 D86 H87 H223
BS03 XQP A Y32 W38 D109 F145 H181 S206 P210 H246 Y9 W15 D86 F122 H158 S183 P187 H223
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7uhp, PDBe:7uhp, PDBj:7uhp
PDBsum7uhp
PubMed36450742
UniProtB2FTM1

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