Structure of PDB 7uhh Chain A

Receptor sequence
>7uhhA (length=264) Species: 522373 (Stenotrophomonas maltophilia K279a) [Search protein sequence]
APLPQLRAYTVDASWLQPMAPLQVADHTWQIGTEDLTALLVQTAEGAVLL
DGGMPQMAGHLLDNMKLRGVAPQDLRLILLSHAHADHAGPVAELKRRTGA
HVAANAETAVLLARGGSNDLHFGDGITYPPASADRIIMDGEVVTVGGIAF
TAHFMPGHTPGSTAWTWTDTRDGKPVRIAYADSLSAPGYQLKGNPRYPRL
IEDYKRSFATVRALPCDLLLTPHPGASNWNYAVGSKASAEALTCNAYADA
AEKKFDAQLARETA
3D structure
PDB7uhh Time-resolved beta-lactam cleavage by L1 metallo-beta-lactamase.
ChainA
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H105 H107 H181 H82 H84 H158
BS02 ZN A D109 H110 H246 D86 H87 H223
BS03 MX0 A Y32 W38 D109 H181 S206 H246 Y9 W15 D86 H158 S183 H223
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7uhh, PDBe:7uhh, PDBj:7uhh
PDBsum7uhh
PubMed36450742
UniProtB2FTM1

[Back to BioLiP]