Structure of PDB 7ud6 Chain A

Receptor sequence
>7ud6A (length=265) Species: 9606,10116 [Search protein sequence]
MLFVALYDYEARTEDDLSFHKGEKFVILRSSEGDWWLAVSLTTGEQGYIP
SNYVAPVGGGTKEQRILEFVQLVAKPGDPQSVLEAIDQYCTYAEWAMNVG
DAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINP
DCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHW
KDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTH
YSSVDGLEKAIYQGP
3D structure
PDB7ud6 Designer installation of a substrate recruitment domain to tailor enzyme specificity.
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.6: catechol O-methyltransferase.
2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A M102 N103 V104 G128 Y130 S134 M151 E152 I153 A180 S181 D203 H204 W205 M97 N98 V99 G123 Y125 S129 M146 E147 I148 A175 S176 D198 H199 W200
Gene Ontology
Molecular Function
GO:0008171 O-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7ud6, PDBe:7ud6, PDBj:7ud6
PDBsum7ud6
PubMed36509904
UniProtP06241|FYN_HUMAN Tyrosine-protein kinase Fyn (Gene Name=FYN);
P22734|COMT_RAT Catechol O-methyltransferase (Gene Name=Comt)

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