Structure of PDB 7ucw Chain A

Receptor sequence
>7ucwA (length=278) Species: 10090 (Mus musculus) [Search protein sequence]
SKDAPQSKFFQPVLKPMLPPDAFQGKVAFITGGGTGLGKAMTTFLSTLGA
QCVIASRNIDVLKATAEEISSKTGNKVHAIRCDVRDPDMVHNTVLELIKV
AGHPDVVINNAAGNFISPSERLTPNGWKTITDIVLNGTAYVTLEIGKQLI
KAQKGAAFLAITTIYAESGSGFVMPSSSAKSGVEAMNKSLAAEWGRYGMR
FNIIQPGPIKEKEMIDRIPCGRLGTMEELANLATFLCSDYASWINGAVIR
FDGGEEVFLSGEFNSLKKVTKEEWDIIE
3D structure
PDB7ucw RNase L-activating 2'-5' oligoadenylates bind ABCF1, ABCF3 and Decr-1.
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.124: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25L A G66 T69 S90 R91 N92 C116 D117 V118 A145 A146 I167 G32 T35 S56 R57 N58 C82 D83 V84 A111 A112 I133
Gene Ontology
Molecular Function
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0070402 NADPH binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:1902494 catalytic complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ucw, PDBe:7ucw, PDBj:7ucw
PDBsum7ucw
PubMed37676257
UniProtQ9CQ62|DECR_MOUSE 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (Gene Name=Decr1)

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