Structure of PDB 7uc7 Chain A

Receptor sequence
>7uc7A (length=557) Species: 9606 (Homo sapiens) [Search protein sequence]
SQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFA
QLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTL
QLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIW
QNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQ
PPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNEN
TRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRASVTEEKFTVL
FESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR
VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSS
HLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGA
ILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNL
KPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDG
YVKPQIK
3D structure
PDB7uc7 Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
ChainA
Resolution3.102 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MQX A R618 S620 D621 S622 T628 N642 L643 K644 P645 F646 R475 S477 D478 S479 T485 N499 L500 K501 P502 F503
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7uc7, PDBe:7uc7, PDBj:7uc7
PDBsum7uc7
PubMed36735833
UniProtP42229|STA5A_HUMAN Signal transducer and activator of transcription 5A (Gene Name=STAT5A)

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