Structure of PDB 7uab Chain A

Receptor sequence
>7uabA (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]
QKDISEINLAAGLDLFQGDILLQKPNTRWTFPIPYILADNLGLNAKGAIL
YAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQG
CAYKAIIEHEILHALGFYHEQSRIWWDQILSGYQHNFDTESLMHYQPFSF
NKNASVPTINSIIGQRLDFSAIDLERHTLLDHCTFEKRDDTDWAHQDSAQ
AGEVDHTYFMQFSTSSGSAEEAALLEPKRKQQCLQFFYKMTGSPSDRLVV
WVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKG
DPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFY
NSEGYGFGVTLYPNSSGYLRLAFHVCSGENDAILEWPVENRQVIITILDQ
EPDVRNRMSSSMVFTTSKSHTSVIWDRPSRVGTYHTDCNCFRSIDLGWSG
FISHQMLKRRSFLKNDDLIIFVDFEDITHLS
3D structure
PDB7uab Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.18: meprin A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC A T351 D384 H386 T241 D274 H276
BS02 CA A D285 T287 D288 D189 T191 D192
BS03 ZN A D58 H155 H159 H165 D19 H109 H113 H119
BS04 CA A T270 E272 T303 Y313 D422 T184 E186 T207 Y208 D312
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uab, PDBe:7uab, PDBj:7uab
PDBsum7uab
PubMed36261433
UniProtQ16819|MEP1A_HUMAN Meprin A subunit alpha (Gene Name=MEP1A)

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