Structure of PDB 7u8u Chain A

Receptor sequence
>7u8uA (length=415) Species: 9606 (Homo sapiens) [Search protein sequence]
PLHSIISSTESVQGSTSKHEFQAETKKLLDIVAEKEVFIRELISNASDAL
EKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNGVG
FYSAFMVADRVEVYSRSAAPSLGYQWLSDGSGVFEIAEASGVRTGTKIII
HLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKD
VREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMSSV
ALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIALIRKLRDVLQQRLIKF
FIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSAL
PSGQLTSLSEYASRIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFD
ELTLLHLREFDKKKL
3D structure
PDB7u8u Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
ChainA
Resolution3.065 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UJY A N119 A123 D158 G162 M163 F205 V217 W231 T251 I253 R368 N45 A49 D84 G88 M89 F101 V113 W126 T146 I148 R255
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7u8u, PDBe:7u8u, PDBj:7u8u
PDBsum7u8u
PubMed37307624
UniProtQ12931|TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial (Gene Name=TRAP1)

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