Structure of PDB 7u8h Chain A

Receptor sequence
>7u8hA (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDCYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKE
3D structure
PDB7u8h Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor.
ChainA
Resolution1.702 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2XO A V7 C39 D54 L56 Y71 T74 V8 C40 D55 L57 Y72 T75
BS02 GDP A G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 G14 V15 G16 K17 S18 A19 F29 D31 N117 K118 D120 S146 A147
BS03 LX6 A V9 E63 Y64 R68 D69 M72 I100 V10 E64 Y65 R69 D70 M73 I101
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7u8h, PDBe:7u8h, PDBj:7u8h
PDBsum7u8h
PubMed36300829
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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