Structure of PDB 7u5v Chain A

Receptor sequence
>7u5vA (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
ALAAASAAAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKR
EKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINID
GQKHIVIFAMRKIYRGEELTYDYA
3D structure
PDB7u5v Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide.
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y3858 E3872 D3876 C3882 Y3883 M3884 F3885 R3886 R3903 Y3944 Y37 E51 D55 C61 Y62 M63 F64 R65 R82 Y123
BS02 SAH A I3838 H3839 R3841 Y3883 F3904 N3906 H3907 Y3944 I17 H18 R20 Y62 F83 N85 H86 Y123
External links
PDB RCSB:7u5v, PDBe:7u5v, PDBj:7u5v
PDBsum7u5v
PubMed37945831
UniProtQ03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

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