Structure of PDB 7u2p Chain A

Receptor sequence
>7u2pA (length=542) Species: 1496 (Clostridioides difficile) [Search protein sequence]
MSLISKEELIKLAYSIRPRENEYKTILTNLDEYNKLTTNNNENKYLQLKK
LNESIDVFMNKYKTSSRNRALSNLKKDILKEVILIKNSNTSPVEKNLHFV
WIGGEVSDIALEYIKQWADINAEYNIKLWYDSEAFLVNTLKKAIVESSTT
EALQLLEEEIQNPQFDNMKFYKKRMEFIYDRQKRFINYYASQINKPTVPT
IDDIIKSHLVSEYNRDETVLESYRTNSLRKINSNHGIDIRANSLFTEQEL
LNIYSQELLNRGNLAAASDIVRLLALKNFGGVYLDVDMLPGIHSDLFKTI
SRPSSIGLDRWEMIKLEAIMKYKKYINNYTSENFDKLDQQLKDNFKLIIE
SKSEKSEIFSKLENLNVSDLEIKIAFALGSVINQALISKQGSYLTNLVIE
QVKNRYQFLNQHLNPAIESDNNFTDTTKIFHDSLFNSATAENSMFLTKIA
PYLQVGFMPEARSTISLSGPGAYASAYYDFINLQENTIEKTLKASDLIEF
KFPENNLSQLTEQEINSLWSFDQASAKYQFEKYVRDYTGGSL
3D structure
PDB7u2p Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition.
ChainA
Resolution2.596 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.-
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UPG A V100 W101 I102 L264 A265 S268 D269 R272 D285 N383 Q384 G469 E514 S517 L518 W519 V100 W101 I102 L264 A265 S268 D269 R272 D285 N383 Q384 G469 E514 S517 L518 W519
BS02 MN A D287 E514 D287 E514
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7u2p, PDBe:7u2p, PDBj:7u2p
PDBsum7u2p
PubMed35637242
UniProtP16154|TCDA_CLODI Toxin A (Gene Name=tcdA)

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