Structure of PDB 7u1a Chain A

Receptor sequence

>7u1aA (length=617) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

SFPEGKPNCLLGLTIVFTGVLPTLERGASEALAKRYGARVTKSISSKTSV
VVLGDEAGPKKLEKIKQLKIKAIDEEGFKQLIAGMPAEGGEAAEKARRKL
EEQHNIATKEAELLVKKEEERSKKLAATVVREEDKLWTVKYAPTNLQQVC
GNKGSVMKLKNWLANWENSKKNSFKHAGKDGSGVFRAAMLYGPPGIGKTT
AAHLVAQELGYDILEQNASDVRSKTLLNAGVKNALDNMSVVGYFKHNEEA
QNLNGKHFVIIMDEVDGMSGGDRGGVGQLAQFCRKTSTPLILICNERNLP
KMRPFDRVCLDIQFRRPDANSIKSRLMTIAIREKFKLDPNVIDRLIQTTR
GDIRQVINLLSTISTTTKTINHENINEISKAWEKNIALKPFDIAHKMLDG
QIYSDIGSRNFTLNDKIALYFDDFDFTPLMIQENYLSTRPSVLKPGQSHL
EAVAEAANCISLGDIVEKKIRSSEQLWSLLPLHAVLSSVYPASKVAGHMA
GRINFTAWLGQNSKSAKYYRLLQEIHYHTRLGTSTDKIGLRLDYLPTFRK
RLLDPFLKQGADAISSVIEVMDDYYLTKEDWDSIMEFFVGPDVTTAIIKK
IPATVKSGFTRKYNSMT

3D structure

PDB

7u1a A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R434 F585 W638	R273 F424 W477
BS02	dna	A	T189 S193 S194 K195 R383 S384 T386 N459 L460 P461 Q474 R476 R477 P551 F552 F587 L590 R632 Q636 F666 W669 L670	T41 S45 S46 K47 R222 S223 T225 N298 L299 P300 Q313 R315 R316 P390 F391 F426 L429 R471 Q475 F505 W508 L509
BS03	dna	A	K195 G315 R476 H556 M660 G662 R663 I664	K47 G154 R315 H395 M499 G501 R502 I503
BS04	AGS	A	T299 A303 P304 C311 P355 G356 I357 G358 K359 T360 T361 N456 R515	T138 A142 P143 C150 P194 G195 I196 G197 K198 T199 T200 N295 R354
BS05	MG	A	T360 D424	T199 D263

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003689	DNA clamp loader activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity

	Biological Process
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006272	leading strand elongation
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0051301	cell division

	Cellular Component
GO:0005634	nucleus
GO:0005663	DNA replication factor C complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7u1a, PDBe:7u1a, PDBj:7u1a
PDBsum	7u1a
PubMed	35731107
UniProt	P38630\|RFC1_YEAST Replication factor C subunit 1 (Gene Name=RFC1)

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