Structure of PDB 7u0u Chain A

Receptor sequence
>7u0uA (length=195) Species: 746128 (Aspergillus fumigatus) [Search protein sequence]
HPYWLPNFMDVFTWSLPFVGEKITDMLIAILNIVSASNFDRDEVDRLRKR
FMKLDKDSSGTIDRDEFLSLPQVSSNPLATRMIAIFDEDGGGDVDFQEFV
SGLSAFSSKGNKEEKLRFAFKVYDIDRDGYISNGELFIVLKMMVGNNLKD
VQLQQIVDKTIMEADKDRDGKISFEEFTEMVENTDVSLSMTLSMF
3D structure
PDB7u0u Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D122 D124 D126 Y128 E133 D124 D126 D128 Y130 E135
BS02 CA A D163 D165 D167 K169 E174 D165 D167 D169 K171 E176
BS03 CA A D53 D55 S57 T59 E64 D55 D57 S59 T61 E66
BS04 CA A D85 D87 D91 E96 D87 D89 D93 E98
BS05 FK5 A W-37 F-33 M141 V142 W14 F18 M143 V144
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity

View graph for
Molecular Function
External links
PDB RCSB:7u0u, PDBe:7u0u, PDBj:7u0u
PDBsum7u0u
PubMed35604094
UniProtQ4WUR1|PP2B_ASPFU Serine/threonine-protein phosphatase 2B catalytic subunit (Gene Name=cnaA)

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