Structure of PDB 7u0s Chain A

Receptor sequence
>7u0sA (length=124) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
FEAQKIEWHEGSSGVTKELKSPGNGVDFPKKGDFVTIHYTGRLTDGSKFD
SSVDRNEPFQTQIGTGRVIKGWDEGVPQMSLGEKAVLTITPDYGYGARGF
PGVIPGNSTLIFEVELLGINNKRA
3D structure
PDB7u0s Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KXX A Y56 D67 F76 V85 W89 Y112 F117 Y39 D50 F59 V68 W72 Y95 F100
BS02 KXX A R115 F117 P118 R98 F100 P101
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:7u0s, PDBe:7u0s, PDBj:7u0s
PDBsum7u0s
PubMed35604094
UniProtQ4WLV6|FKB1A_ASPFU FK506-binding protein 1A (Gene Name=fpr1A)

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