Structure of PDB 7tyb Chain A

Receptor sequence
>7tybA (length=523) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
APDWPAAFVRRYLDAGHWQDQSFAEALATSAARHPRRIALCDDDQRLSYA
DLLQRCRRLAAGLRQAGLAHGDTVVLHLPNGIAFVETCFALFQLGVRPVL
ALPAHRQHEISGFCRFAEAKAYIGAERIDGFDPRPMARELLASGACRMAL
IHGEAEAPLQALAPLYQADALEDCAARAEDIACFQLSGTPKLIPRRHREY
LYNVRASAEVCGFDEHTVYLTGLPMAHNFTLCCPGVIGTLLASGRVVVSQ
RADPEHCFALIARERVTHTALVPPLAMLWLDAQESRRADLSSLRLLQVGG
SRLGSSAAQRVEPVLGCQLQQVLGMAEGLICYTRLDDPPERVLHTQGRPL
SPDDEVRVVDAEGREVGPGEVGELTVRGPYTIRGYYRLPEHNAKAFSADG
FYRTGDRVSRDKDGYLVVEGRDKDQINRGGEKIAAEEVENLLIAHPQVHD
ATVVAMPDSLLGERTCAFVIPRQPAPSALKLKQYLHACGLAAFKVPDRIE
LVPAFPQTGIGKISKKDLRERLR
3D structure
PDB7tyb Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD.
ChainA
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.61: salicylate--[aryl-carrier protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KT0 A H244 N245 F246 C250 G317 S318 R319 V339 L340 G341 M342 A343 Q363 D423 V435 R438 K529 H227 N228 F229 C233 G300 S301 R302 V322 L323 G324 M325 A326 Q346 D406 V418 R421 K512
Gene Ontology
Molecular Function
GO:0016874 ligase activity
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7tyb, PDBe:7tyb, PDBj:7tyb
PDBsum7tyb
PubMed35513576
UniProtQ9HWG3|PCHD_PSEAE Pyochelin synthase PchD (Gene Name=pchD)

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