Structure of PDB 7tw8 Chain A

Receptor sequence
>7tw8A (length=264) Species: 9606,2697049 [Search protein sequence]
LPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTK
EDFRYRSPHSGDELYELLQHILAQPAAGDELKINAACRKVQHMVVKAALL
ADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYAT
HSDKFTDGVCLFWNCNVDRYPANSIVCRFDKSAFVNLKQLPFFYYSDSPC
ESHYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVY
KQFDTYNLWNTFTR
3D structure
PDB7tw8 High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A R310 G333 P335 D352 A353 F367 Y368 W385 C387 R88 G111 P113 D130 A131 F145 Y146 W163 C165
BS02 ZN A C452 C477 C484 H487 C200 C216 C223 H226
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004532 RNA exonuclease activity
GO:0008168 methyltransferase activity
GO:0043565 sequence-specific DNA binding

View graph for
Molecular Function
External links
PDB RCSB:7tw8, PDBe:7tw8, PDBj:7tw8
PDBsum7tw8
PubMed36075969
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep);
P41212|ETV6_HUMAN Transcription factor ETV6 (Gene Name=ETV6)

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