Structure of PDB 7tvb Chain A

Receptor sequence
>7tvbA (length=558) Species: 9606 (Homo sapiens) [Search protein sequence]
MSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQF
AQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKT
LQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEII
WQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEK
QPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE
NTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRASVTEEKFTV
LFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPG
RVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSS
SHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDG
AILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWN
LKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVD
GYVKPQIK
3D structure
PDB7tvb A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
ChainA
Resolution2.653 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KOC A K600 R618 S620 D621 S622 T628 N642 L643 K644 P645 F646 D650 L663 Y665 K458 R476 S478 D479 S480 T486 N500 L501 K502 P503 F504 D508 L521 Y523
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7tvb, PDBe:7tvb, PDBj:7tvb
PDBsum7tvb
PubMed36732620
UniProtP42229|STA5A_HUMAN Signal transducer and activator of transcription 5A (Gene Name=STAT5A)

[Back to BioLiP]