Structure of PDB 7tuv Chain A

Receptor sequence

>7tuvA (length=672) Species: 5691 (Trypanosoma brucei) [Search protein sequence]

ALFSPHLAESALDLGVQNGTYLRGKLRVSETNCFFGEIRGQWKGHNFERV
LLPGRTNLNRAIHGDIVTVELLPVASWRPLREESEGAALARGYTPVGRVV
GITTMNRRPFCGSIDVEELNKLALTGTVSVLFQPKDNRIPRIRITTAHLG
DLKDKRLSVIIDDWGEHSSFPVGHYVEVLGTIGDKDTEAKVILLENDIPH
YDFSEAVYDCLPKGEWNVTEEELGNRLDLRDLCVVSVDPLGCRDIDDALH
CRRVNGNHLEVGVHIADVTHFLKEGTAMDEEAAKRSTSVYLVDRRINMLP
QLLTENLCSIVADEDRYAFSIMWEFDENYSVVREFFGKTVIRSRAALYYG
DAQRMIDDPEDESEAAVSLRYLMQLSRHFRKRREKDGALFLCSQEFKFKV
DNDHVNPTDMQAYQTFDSNSMIEEWMLFANAAAARRVYASFPRWTLLRRH
QAPAENAFDTLNEAIRRKIGVKLDDTTSLALNESLEKCVDPSDPYFNRLI
RTLVTRCLRQAQYFSSSEVSKDEFHHFGLAMPIYTHFTSPIRRYADVIVH
RQLAAALGIMDVSEHMVSVKMEALASNLNYRHEQAQKAGRDSQNLFTGFY
LRNFANQEIPSEDGYVVKLSETHVFVLVPKYGQEGKIAKETLVRVPNLLD
KVKVGIEVRASLVFSIIGLMKG

3D structure

PDB

7tuv Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates.

Chain

Resolution

2.225 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	D503 P504 Y614 L656 S658 E688 M691 L692 R713 H715 Q775 A776 H791 L794 Y799 H801 T803 R807	D238 P239 Y349 L391 S393 E423 M426 L427 R448 H450 Q510 A511 H526 L529 Y534 H536 T538 R542
BS02	U5P	A	P504 C507 D509 Y555 R807	P239 C242 D244 Y290 R542
BS03	MG	A	D503 D511 D512	D238 D246 D247
BS04	MG	A	D511 S804	D246 S539

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004540	RNA nuclease activity

View graph for
Molecular Function

External links

PDB	RCSB:7tuv, PDBe:7tuv, PDBj:7tuv
PDBsum	7tuv
PubMed	36583334
UniProt	Q95Z12

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