Structure of PDB 7tun Chain A

Receptor sequence
>7tunA (length=377) Species: 9606 (Homo sapiens) [Search protein sequence]
NSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRAKSTPSGFTLD
DVIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKPSD
EHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAI
EKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLA
SGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFC
TGLTQIETLFKSKDYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPNLGK
HEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVV
DGVKLLIEMEQRLEQGQAIDDLMPAQK
3D structure
PDB7tun Crystal Structure Analysis of human CKB complex with a covalent compound
ChainA
Resolution2.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.3.2: creatine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KLU A T59 T71 V72 G73 V75 L202 S205 C283 T55 T67 V68 G69 V71 L198 S201 C279
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004111 creatine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0016310 phosphorylation
GO:0021762 substantia nigra development
GO:0046314 phosphocreatine biosynthetic process
GO:0140651 futile creatine cycle
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tun, PDBe:7tun, PDBj:7tun
PDBsum7tun
PubMed
UniProtP12277|KCRB_HUMAN Creatine kinase B-type (Gene Name=CKB)

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