Structure of PDB 7tt8 Chain A

Receptor sequence
>7tt8A (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
ASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANKLSTFGLMCKMADQTL
FSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSI
FLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKF
LVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRL
PEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHA
3D structure
PDB7tt8 Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R361 M375 Q379 N530 L531 E534 M535 R58 M72 Q76 N227 L228 E231 M232
BS02 IUW A F342 M345 C346 M348 A349 H390 L405 V406 A420 G421 L424 M428 Y516 K520 F39 M42 C43 M45 A46 H87 L102 V103 A117 G118 L121 M125 Y213 K217
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:7tt8, PDBe:7tt8, PDBj:7tt8
PDBsum7tt8
PubMed35503419
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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