Structure of PDB 7ts4 Chain A

Receptor sequence
>7ts4A (length=419) Species: 9606 (Homo sapiens) [Search protein sequence]
RFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDV
ATKDQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKD
TELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKY
ATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPAN
VQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRH
PKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDY
CDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTI
VDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNY
RLTPSFEYQPDPWNTHVWK
3D structure
PDB7ts4 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
ChainA
Resolution1.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A W414 C420 F589 W592 E597 W683 F709 Y711 W111 C117 F286 W289 E294 W380 F406 Y408
BS02 H4B A S339 M341 R601 V682 W683 S36 M38 R298 V379 W380
BS03 K90 A P570 V572 F589 W592 E597 P267 V269 F286 W289 E294
BS04 ZN A C331 C336 C28 C33
BS05 H4B A F696 Q698 E699 F393 Q395 E396
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ts4, PDBe:7ts4, PDBj:7ts4
PDBsum7ts4
PubMed35772285
UniProtP29475|NOS1_HUMAN Nitric oxide synthase 1 (Gene Name=NOS1)

[Back to BioLiP]