Structure of PDB 7tqq Chain A

Receptor sequence
>7tqqA (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
PGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTTVPPPPRV
VDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLR
RQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALE
RASSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAH
ARPFGTIRPMYG
3D structure
PDB7tqq Structural basis of human TREX1 DNA degradation and autoimmune disease.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D18 E20 A21 L24 F26 A80 I84 T85 N125 R128 Y129 S176 Y177 S178 L179 D11 E13 A14 L17 F19 A67 I71 T72 N112 R115 Y116 S154 Y155 S156 L157
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:7tqq, PDBe:7tqq, PDBj:7tqq
PDBsum7tqq
PubMed35879334
UniProtQ9NSU2|TREX1_HUMAN Three-prime repair exonuclease 1 (Gene Name=TREX1)

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