Structure of PDB 7tpt Chain A

Receptor sequence
>7tptA (length=414) Species: 9913 (Bos taurus) [Search protein sequence]
GRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVM
KGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLR
AEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAAS
WTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITY
FIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKW
IKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDE
VIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEE
LSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEE
IGPSICRHNPVFGV
3D structure
PDB7tpt Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy.
ChainA
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A T14 G15 G171 D172 K228 G324 R374 T12 G13 G169 D170 K226 G322 R372
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0010592 positive regulation of lamellipodium assembly
GO:0030030 cell projection organization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060271 cilium assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0035861 site of double-strand break
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tpt, PDBe:7tpt, PDBj:7tpt
PDBsum7tpt
PubMed35622886
UniProtP61157|ARP3_BOVIN Actin-related protein 3 (Gene Name=ACTR3)

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