Structure of PDB 7toc Chain A

Receptor sequence
>7tocA (length=359) Species: 498019 (Candidozyma auris) [Search protein sequence]
VVSAAPLATRGLKTINFGGTEEVVHERADWPREKLLEYFKNDTMALIGYG
SQGYGQGLNLRDNGLNVIIGVRKNGASWKAAIEDGWVPGENLFDVKEAIT
KGTIIMNLLSDAAQSETWPDLKPLITEGKTLYFSHGFSPVFKDLTKVEPP
SNVDVILAAPKGSGRTVRSLFLEGRGINSSYAVWNDVTGKAEEKAIAMAV
AIGSGYVYQTTFEREVNSDLYGERGCLMGGIHGMFLAQYEVLRENGHTPS
EAFNETVEEATQSLYPLIGKYGMDYMYDACSTTARRGALDWYPRFKDALK
PVFVELYESVKNGTETQRSLDFNGAPDYRERLEEELETIRNMEIWKVGKE
VRKLRPENQ
3D structure
PDB7toc Crystal Structure of the Mitochondrial Ketol-acid Reductoisomerase IlvC from Candida auris
ChainA
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.86: ketol-acid reductoisomerase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A G89 G91 S92 Q93 R113 S118 L149 L150 S151 D152 A154 E157 H176 G203 S204 Y369 R370 G48 G50 S51 Q52 R72 S77 L108 L109 S110 D111 A113 E116 H135 G162 S163 Y328 R329
BS02 MG A D260 E264 D219 E223
BS03 NDP A S322 T323 S281 T282
BS04 MG A K202 D260 K161 D219
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004455 ketol-acid reductoisomerase activity
GO:0016491 oxidoreductase activity
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7toc, PDBe:7toc, PDBj:7toc
PDBsum7toc
PubMed
UniProtA0A2H0ZMH9

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