Structure of PDB 7tm7 Chain A

Receptor sequence

>7tm7A (length=802) Species: 1125630 (Klebsiella pneumoniae subsp. pneumoniae HS11286)

HHHHHHMSQTTFNKAQFQAALTRQWQHFGLQSASEMTQRQWWRAVSGALA
ELLAAQPVAKPAQGQRHVNYISMEFLIGRLTGNNLLNLGWYEGVSDALKG
YDVNLTDLLEEETDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQYG
LFRQSFDDGQQMEAPDDWGRSSYPWFRHNEALDVQVGIGGKVSKNGEWQP
AFVITGEAWDLPVLGYRNNVAQPLRLWQAKHAHPFNLTKFNDGDFLRAEQ
QGIDAEKLTKVLYPNDNHQAGKKLRLMQQYFQCACSVADILRRHHLAGRK
LAELADYEVIQLNDTHPTIAIPELLRVLIDEHQLSWDDAWAITSKTFAYT
NHTLMPEALECWDEKLVKALLPRHMQIIKEINDRFKQLVDKTWPGDKQVW
AKLAVVHDKQVRMANMCVVGGFAVNGVAALHSDLVVKDLFPEYNQLWPNK
FHNVTNGITPRRWIKQCNPALASLLDETLKKEWANDLDQLINLEKYADDA
AFRQTYRDIKQANKVHLAEFVKQRTGIEINPQAIFDIQIKRLHEYKRQHL
NLLHILALYKEIRENPQSDRVPRVFLFGAKAAPGYYLAKNIIFAINKVAE
AINNDPKVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGN
MKLALNGALTVGTLDGANVEIAEQVGEENIFIFGHTVEEVKALKAKGYDP
LKWRKKDKLLDAVLKELENGTYSNGDKHAFDQMLHSLLQGGDPYLVLADF
EAYVAAQKRVDELYRDEEAWTRAAILNTARCGMFSSDRSIRDYQQRIWQA
KR

3D structure

• PDB: 7tm7 Crystal structure of Alpha-1,4 glucan phosphorylase from Klebsiella pneumoniae
• Chain: A
• Resolution: 1.91 Å

Enzymatic activity

• Enzyme Commision number: 2.4.1.1: glycogen phosphorylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	A	L70 W457 K534 Y614 V616 T642 G643 K646	L76 W463 K540 Y620 V622 T648 G649 K652

Gene Ontology

Molecular Function

• GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
• GO:0008184 glycogen phosphorylase activity
• GO:0016757 glycosyltransferase activity
• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0005980 glycogen catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7tm7, PDBe:7tm7, PDBj:7tm7
• PDBsum: 7tm7
• UniProt: A0A0H3GYH4