Structure of PDB 7tl8 Chain A

Receptor sequence

>7tl8A (length=488) Species: 1280 (Staphylococcus aureus)

MAKKPTALIILDGFANRESEHGNAVKLANKPNFDRYYNKYPTTQIEASGL
DVGLPEGQMGNSEVGHMNIGAGRIVYQSLTRINKSIEDGDFFENDVLNNA
IAHVNSHDLHIFGLLSDGGVHSHYKHLFALLELAKKQGVEKVYVHAFLDG
RDVDQKSALKYIEETEAKFNELGIGQFASVSGRYYAMDRDKRWEREEKAY
NAINFDAPTYATAKEGVEASYNEGLTDEFVVPFIVENQNDGVVIFYNFRP
DRAAQLSEIFANQVKDLFYATFTKYNDNIDAAIVFEKVDLNNTIGEIAQN
NNLTQLRIAETEKYPHVTYFMSGGRNEEFKGERRRLIDSPKVATYDLKPE
MSAYEVKDALLEELNKGDLDLIILNFANPDMVGHSGMLEPTIKAIEAVDE
CLGEVVDKILDMDGYAIITADHGNSDQVLTDDDQPMTTHTTNPVPVIVTK
EGVTLRETGRLGDLAPTLLDLLNVEQPEDMTGESLIKH

3D structure

• PDB: 7tl8 Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases.
• Chain: A
• Resolution: 1.95 Å

Enzymatic activity

• Enzyme Commision number: 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	N61 E63 V64 M67 Q77 S78 V122 H123 R191 R257 R260 T290 P332 F337	N61 E63 V64 M67 Q77 S78 V120 H121 R189 R249 R252 T273 P315 F320
BS02	MN	A	D12 S62 D438 H439	D12 S62 D421 H422
BS03	MN	A	D397 H401 H456	D380 H384 H439

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004619 phosphoglycerate mutase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006007 glucose catabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7tl8, PDBe:7tl8, PDBj:7tl8
• PDBsum: 7tl8
• PubMed: 35904259
• UniProt: Q5HHP2|GPMI_STAAC 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Gene Name=gpmI)