Structure of PDB 7tkt Chain A

Receptor sequence
>7tktA (length=390) Species: 869211 (Spirochaeta thermophila DSM 6578) [Search protein sequence]
TYTLVWKVWILAVTLYYAIRIPLTLVFPSLFSPLLPLDILASLALIADIP
LDLSRLPDLLAALPLDLLVFALHLPSPLSLLSLVRLLKLISVQRSATRIL
SYRINPALLRLLSLVGFILLAAHGIACGWMSLQPPSENPAGTRYLSAFYW
TITTLTTIGYGDITPSTPTQTVYTIVIELLGAAMYGLVIGNIASLVSKLD
AAKLLHRERVERVTAFLSYKRISPELQRRIIEYFDYLWETRRGYEEREVL
KELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGE
YIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAP
RTATVRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAV
3D structure
PDB7tkt Anionic lipids unlock the gates of select ion channels in the pacemaker family.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A F366 G367 E368 M369 R377 T378 A379 F340 G341 E342 M343 R351 T352 A353
BS02 PGW A L34 L100 S102 S157 L158 L25 L74 S76 S131 L132
BS03 PGW A L115 F143 L89 F117
BS04 PGW A G167 F174 G141 F148
BS05 PGW A L32 Y170 L23 Y144
BS06 PGW A A209 L213 A183 L187
Gene Ontology
Molecular Function
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7tkt, PDBe:7tkt, PDBj:7tkt
PDBsum7tkt
PubMed36352139
UniProtG0GA88

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