Structure of PDB 7tjh Chain A

Receptor sequence
>7tjhA (length=483) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
VIRKFTKKNVARAKKKYTPFSKRFKSIAAIPDLTSLPEFYGNRFENKLKT
TQKHQIVETIFSKVKKQLNSSLPARENEFASIYLSAYSAIESDSATTIYV
AGTPGVGKTLTVREVVKELLSSSAQREIPDFLYVEINGLKMVKPTDCYET
LWNKVSGERLTWAASMESLEFYFKRVPKNKKKTIVVLLDELDAMVTKSQD
IMYNFFNWTTYENAKLIVIAVANTMDLPERQLGNKITSRIGFTRIMFTGY
THEELKNIIDLRLKGLNDSFFYVDTKTGNAILIVRKVRLRMSADAIEIAS
RKVASVSGDARRALKVCKRAAEIAEKHYMAKHGYGYDGVQTVHITHVMKA
LNETLNSHVITFMTRLSFTAKLFIYALLNLMKKNGSQEQELGDIVDEIKL
LIEVNGSNKFVMEIAKTLFQQGSDNISEQLRIISWDFVLNQLLDAGILFK
QTMKNDRICCVKLNISVEEAKRAMNEDETLRNL
3D structure
PDB7tjh A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F360 K362 R367 Y372 K520 T538 W539 F5 K7 R12 Y17 K143 T161 W162
BS02 dna A R358 K359 F360 K362 R367 K369 K371 Y372 T373 R3 K4 F5 K7 R12 K14 K16 Y17 T18
BS03 ATP A S432 P481 G482 G484 K485 T486 L487 Y627 I635 R639 R704 S70 P104 G105 G107 K108 T109 L110 Y250 I258 R262 R311
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0031491 nucleosome binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0030466 silent mating-type cassette heterochromatin formation
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0034728 nucleosome organization
GO:0043007 maintenance of rDNA
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0005694 chromosome
GO:0031261 DNA replication preinitiation complex
GO:0032993 protein-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tjh, PDBe:7tjh, PDBj:7tjh
PDBsum7tjh
PubMed35217664
UniProtP54784|ORC1_YEAST Origin recognition complex subunit 1 (Gene Name=ORC1)

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