Structure of PDB 7tj9 Chain A

Receptor sequence
>7tj9A (length=1111) Species: 9606 (Homo sapiens) [Search protein sequence]
CTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLE
NTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSP
LDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFL
SIFSLIGMGLFMGNLKHKCFRWPQTGNPYYIRETENFYYLEGERYALLCG
NRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVL
YHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVMAPF
TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKI
IAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKL
GKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEF
VCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCI
PFYLMVILIGNLLVLYLFLALVSSFSSQNIRKTCCKIVENNWFKCFIGLV
TLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFK
AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFER
MKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG
ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNG
WITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVII
DNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGF
IFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVML
YTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPS
LVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFI
YAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAI
FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIV
VVMEFLNIASK
3D structure
PDB7tj9 Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A Q352 I1432 I1487 Y1491 Q244 I1039 I1094 Y1098
BS02 CLR A M1225 I1354 L1357 R1358 M1374 M832 I961 L964 R965 M981
BS03 Q7G A Q236 G239 V240 I242 F246 C1262 M1269 K1364 V1365 F1366 Q138 G141 V142 I144 F148 C869 M876 K971 V972 F973
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 monoatomic cation channel activity
GO:0005272 sodium channel activity
GO:0044325 transmembrane transporter binding
GO:1990760 osmolarity-sensing monoatomic cation channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0007231 osmosensory signaling pathway
GO:0009617 response to bacterium
GO:0019725 cellular homeostasis
GO:0035725 sodium ion transmembrane transport
GO:0055078 sodium ion homeostasis
GO:0055085 transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0097386 glial cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tj9, PDBe:7tj9, PDBj:7tj9
PDBsum7tj9
PubMed35301303
UniProtQ01118|SCN7A_HUMAN Sodium channel protein type 7 subunit alpha (Gene Name=SCN7A)

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