Structure of PDB 7tin Chain A

Receptor sequence
>7tinA (length=555) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
GNHKAALTKQVFTFASELYAYGVREVVISPGSRSTPLALAFEAHPNIKTW
IHPDERSAAFFAVGLIKGSERPVAILCTSGTAAANYTPAIAESQISRIPL
IVLTSDRPHELRSVGAPQAINQVNMFNNYVSYEFDMPIADDSKETINAIY
YQMQIASQYLYGPHKGPIHFNLPFRDPLTPDLNATELLTSEMKILPHYQK
SIDASALRHILNKKKGLIIVGDMQHQEVDQILTYSTIYDLPILADPLSHL
RKFDHPNVICTYDLLFRSGLDLNVDFVIRVGKPVISKKLNQWLKKTDAFQ
ILVQNNDKIDVFPIAPDISYEISANDFFRSLMEDTTINRVSWLEKWQCLE
KKGRKEIKCYLEQATDESAFVGELIKKTSEKDALFISNSMPIRDVDNLLL
NKNIDVYANRGANGIDGIVSTALGMAVHKRITLLIGDLSFYHDMNGLLMS
KLNNIQMNIVLLNNDGGGIFSYLPQKESATDYFERLFGTPTGLDFEYTAK
LYQFDFKRFNSVSEFKNATLLSETSTIYELITNREDNFKQHQILYQKLSE
MIHDT
3D structure
PDB7tin Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.9: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP A S390 M391 I416 D438 L439 S440 N465 G467 G469 I470 F471 S389 M390 I415 D437 L438 S439 N464 G466 G468 I469 F470
BS02 GLY A D107 R108 R113 S114 A120 I121 D106 R107 R112 S113 A119 I120
BS03 CA A D438 N465 G467 D437 N464 G466
BS04 TPP A P31 E56 A83 P30 E55 A82
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0030145 manganese ion binding
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding
GO:0070204 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
Biological Process
GO:0009234 menaquinone biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7tin, PDBe:7tin, PDBj:7tin
PDBsum7tin
PubMed36633276
UniProtQ2FZL7|MEND_STAA8 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (Gene Name=menD)

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