Structure of PDB 7ti2 Chain A

Receptor sequence
>7ti2A (length=262) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
AEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAV
LARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYS
DNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDT
SSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWA
VGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAA
AARLALEGLGVN
3D structure
PDB7ti2 Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZXQ A S45 K48 W80 S105 N107 L142 N145 T210 G211 T212 S40 K43 W75 S100 N102 L137 N140 T205 G206 T207
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:7ti2, PDBe:7ti2, PDBj:7ti2
PDBsum7ti2
PubMed35358864
UniProtQ9F663|BLKPC_KLEPN Carbapenem-hydrolyzing beta-lactamase KPC (Gene Name=bla)

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