Structure of PDB 7ti1 Chain A

Receptor sequence
>7ti1A (length=359) Species: 550 (Enterobacter cloacae) [Search protein sequence]
VSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANK
PVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQWQ
GIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYAN
ASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWG
YRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGI
ALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVN
PPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEA
AYHILEALQ
3D structure
PDB7ti1 Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZXQ A S84 L139 Q140 Y170 Y241 S338 T339 N366 S62 L117 Q118 Y148 Y219 S316 T317 N344
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ti1, PDBe:7ti1, PDBj:7ti1
PDBsum7ti1
PubMed35358864
UniProtP05364|AMPC_ENTCL Beta-lactamase (Gene Name=ampC)

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