Structure of PDB 7ti0 Chain A

Receptor sequence
>7ti0A (length=260) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
TADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMA
AAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAA
LQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGD
PRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLP
ASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDV
LASAAKIVTD
3D structure
PDB7ti0 Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZXQ A S45 N79 Y80 S105 N107 P142 N145 T210 G211 S212 S44 N78 Y79 S104 N106 P141 N144 T209 G210 S211
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:7ti0, PDBe:7ti0, PDBj:7ti0
PDBsum7ti0
PubMed35358864
UniProtQ2PUH3

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