Structure of PDB 7thy Chain A

Receptor sequence
>7thyA (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
YNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIR
DKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAM
KPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPA
IRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPD
3D structure
PDB7thy Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules.
ChainA
Resolution5.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G1344 G1346 T1348 T1349 M1364 Q1365 A1367 T1368 H1453 G13 G15 T17 T18 M33 Q34 A36 T37 H122
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7thy, PDBe:7thy, PDBj:7thy
PDBsum7thy
PubMed36510024
UniProtQ5S007|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

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