Structure of PDB 7thv Chain A

Receptor sequence
>7thvA (length=477) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
VREEDKLWTVKYAPTNLQQVCGNKGSVMKLKNWLANWENSKKNSFKHAGK
DGSGVFRAAMLYGPPGIGKTTAAHLVAQELGYDILEQNASDVRSKTLLNA
GVKNALDNMSVVGYFKHNEEAQNLNGKHFVIIMDEVDGMSGGDRGGVGQL
AQFCRKTSTPLILICNERNLPKMRPFDRVCLDIQFRRPDANSIKSRLMTI
AIREKFKLDPNVIDRLIQTTRGDIRQVINLLSTISTSKAWEKNIALKPFD
IAHKMLDGQIYSDIGSRNFTLNDKIALYFDDFDFTPLMIQENYLSTRPSV
LKPGQSHLEAVAEAANCISLGDIVEKKIRSSEQLWSLLPLHAVLSSVYPA
SKVAGHMAGRINFTAWLGQNSKSAKYYRLLQEIHYHTRLGTSTDKIGLRL
DYLPTFRKRLLDPFLKQGADAISSVIEVMDDYYLTKEDWDSIMEFFVGPD
VTTAIIKKIPATVKSGFTRKYNSMTHP
3D structure
PDB7thv Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader.
ChainA
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A T299 A303 C311 I357 G358 K359 T360 T361 N456 I514 R515 T9 A13 C21 I67 G68 K69 T70 T71 N166 I224 R225
BS02 MG A T360 D424 T70 D134
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7thv, PDBe:7thv, PDBj:7thv
PDBsum7thv
PubMed35179493
UniProtP38630|RFC1_YEAST Replication factor C subunit 1 (Gene Name=RFC1)

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