Structure of PDB 7thm Chain A

Receptor sequence
>7thmA (length=860) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
SFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKCRFQE
KDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKVPHISRQR
LTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVEN
PDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYD
FGDFIQPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTKPYIKWDLLKY
DFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPP
TSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSFKELLVYAAD
PAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKG
FFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVD
KYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMQDALFAYT
KRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAA
TRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLR
IMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTS
SGDATTAYANSVFNICQAVTANVNALLSTDGNKDKYVRNLQHRLYECLYR
NRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFK
SVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQYVYLPYPDPSR
ILGAGCFVDDIMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLEP
EFYEAMYTPH
3D structure
PDB7thm The mechanism of RNA capping by SARS-CoV-2.
ChainA
Resolution3.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H295 C301 C306 H272 C278 C283
BS02 ZN A C487 H642 C646 C460 H611 C615
BS03 MN A N209 D218 N191 D200
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7thm, PDBe:7thm, PDBj:7thm
PDBsum7thm
PubMed35944563
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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