Structure of PDB 7thi Chain A

Receptor sequence
>7thiA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
SKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFE
FDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNRE
QMALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQ
LPRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEG
ISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQ
GKVKQ
3D structure
PDB7thi Human Bisphosphoglycerate Mutase complexed with 2-phosphoglycolate
ChainA
Resolution1.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.4.2.11: phosphoglycerate mutase (2,3-diphosphoglycerate-dependent).
5.4.2.4: bisphosphoglycerate mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGA A S24 E89 Y92 R100 R116 R117 S23 E88 Y91 R99 R115 R116
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004082 bisphosphoglycerate mutase activity
GO:0004619 phosphoglycerate mutase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046538 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0006753 nucleoside phosphate metabolic process
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0015671 oxygen transport
GO:0033554 cellular response to stress
GO:0042832 defense response to protozoan
GO:0048821 erythrocyte development
GO:0060856 establishment of blood-brain barrier
GO:0150076 neuroinflammatory response
GO:1901136 carbohydrate derivative catabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7thi, PDBe:7thi, PDBj:7thi
PDBsum7thi
PubMed
UniProtP07738|PMGE_HUMAN Bisphosphoglycerate mutase (Gene Name=BPGM)

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