Structure of PDB 7tgl Chain A

Receptor sequence

>7tglA (length=590) Species: 35619 (Streptomyces griseoflavus)

MSLTDAVAHLSPERWEEANRLLVRKALAEFAHERLFTPEPADGQDGRYVV
RSDDGLTSYRFTAVRRALDHWQVDAGSITRTRDGAELPLAALDFFIELRH
TLGLSDEILPVYLEEISSTLSGTCYKLTKPQVTAAGLLEGGFQALESGMT
EGHPCFVANNGRLGFGVDEYLAYAPETAHPVRLVWLAAHRSRAAFTAGAG
IDYASFVRQELGEETVERFDGVLRGRGLDPADYLLIPVHPWQWWNKLSVT
FAAEVARQNLVCLGESDDEYLAQQSIRTFFNATHPEKHYVKTALSVLNMG
FMRGLSAAYMEATPAINDWLDRLIDNDPVLKSTGLSIIRERAAVGYRHLE
YEAATDRYSPYRKMLAALWRESPVPALRDGESLTTMAALVHVDHEGRSVA
GELIARSGLAPTAWLRHYLRAYYTPLLHSFYAYDLAFMPHGENTILVLKD
GVVQRAVYKDIAEEIVVMDPDAVLPPEVRRVRAEVPEDMKLLSIFTDVFD
CFFRFLAAGLATEEVLAEDDFWRTVAEVTREYQEAHPELDDRFRQYDLFA
PEFALSCLNRLQLRDNRQMVDLADPSAALQLVGTLRNPLA

3D structure

• PDB: 7tgl An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD.
• Chain: A
• Resolution: 2.89 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AMP	A	G152 H153 Q274 M299 R303 H440 E442 N443 D460 E464	G152 H153 Q274 M299 R303 H440 E442 N443 D460 E464
BS02	MG	A	D460 E463 E464	D460 E463 E464
BS03	MG	A	E442 N443 D460	E442 N443 D460

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sat Nov 16 22:45:22 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '7tgl', asym_id = 'A', title = 'An acyl-adenylate mimic reveals the structural b...ion by the iterative siderophore synthetase DesD.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='7tgl', asym_id='A', title='An acyl-adenylate mimic reveals the structural b...ion by the iterative siderophore synthetase DesD.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0019290', uniprot = '', pdbid = '7tgl', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0019290', uniprot='', pdbid='7tgl', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>