Structure of PDB 7tfl Chain A

Receptor sequence
>7tflA (length=338) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
REEDKLWTVKYAPTNLQQVCGNKGSVMKLKNWLANWENSKDGSGVFRAAM
LYGPPGIGKTTAAHLVAQELGYDILEKHFVIIMDEVDGMSGGDRGGVGQL
AQFCRKTSTPLILICNERNLPKMRPFDRVCLDIQFRRPDANSIKSRLMTI
AIREKFKLDPNVIDRLIQTTRGDIRQVINLLSTISTTTKTINHENINEIS
KAWEKNIALKPFDIAHKMLDGQIYSDIGSRNFTLNDKIALYFDDFDFTPL
MIQENYLSTRPSVLKPGQSHLEAVAEAANCISLGDIVEKKIRSSEQLWSL
LPLHAVLSSVYPASKVAGHMAGRINFTAWLGQNSKSAK
3D structure
PDB7tfl Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
ChainA
Resolution3.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D586 R632 Q636 W638 W669 L670 D246 R292 Q296 W298 W329 L330
BS02 dna A F582 W638 S639 P642 F242 W298 S299 P302
BS03 AGS A T299 C311 G356 I357 G358 K359 T360 T361 E425 N456 I514 R515 T8 C20 G56 I57 G58 K59 T60 T61 E85 N116 I174 R175
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tfl, PDBe:7tfl, PDBj:7tfl
PDBsum7tfl
PubMed35829698
UniProtP38630|RFC1_YEAST Replication factor C subunit 1 (Gene Name=RFC1)

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