Structure of PDB 7tdp Chain A

Receptor sequence

>7tdpA (length=439) Species: 1406 (Paenibacillus polymyxa)

SYTREDIIRIAEEENVRFIRLQFTDLLGTIKNVEIPVSQLEKALDNKMMF
DGSSIEGYVRIEESDMYLYPDLDTWVVFPWSDRVARLICDIYKPDGSPFA
GDPRGILKRVLKEAEELGYTSMNVGPEPEFFLFKTDEKGDPTTELNDQGG
YFDLAPMDLGENCRREIVLKLEEMGFEIEASHHEVAPGQHEIDFKYADAV
KAADQIQTFKLVVKTIARQHGLHATFMPKPLFGVNGSGMHCNQSLFKDNE
NVFYDETDELGLSQTARHYMAGILKHARAMAAITNPTVNSYKRLVPGYEA
PCYVAWSASNRSPMIRIPASRGLSTRVEVRNPDPAANPYLALAVMLRAGL
DGIKRQMALPAPIDRNIYVMSEEERIEEGIPSLPADLKEALSELIRSEVI
SDALGDHALAYFYELKEIEWDMYRTQVHQWERDQYLTLY

3D structure

• PDB: 7tdp Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
• Chain: A
• Resolution: 1.98 Å

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	N126 G128 E130 E182 D196 Y199 N245 S247 R319 R329	N123 G125 E127 E179 D193 Y196 N242 S244 R316 R326
BS02	P3S	A	E130 E132 E187 E194 G239 H243 R296 E302 R314 R333	E127 E129 E184 E191 G236 H240 R293 E299 R311 R330
BS03	MG	A	E132 E187 E194	E129 E184 E191
BS04	MG	A	E130 H243 E331	E127 H240 E328
BS05	MG	A	E130 E194	E127 E191

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7tdp, PDBe:7tdp, PDBj:7tdp
• PDBsum: 7tdp
• PubMed: 35778410
• UniProt: A0A0F0G8G2