Structure of PDB 7tbv Chain A

Receptor sequence

>7tbvA (length=682) Species: 1165368 (Candida albicans Ca6)

SSDKSIIVIGMRGTGKSTLSEWLASFLGFKMLDMDKYLEEKLGTGIKSLI
KAKGWEYFRQEEAIVAKECFTKFSKGYVLSTGGGIVEGEDARQQLKSYAD
NGGIVLHLHRDLDESSEVQEVWLRREKWYHECSNYHFYSSHCSTEDEFNH
LRRSFVNYIKLITGAERPVVPVGRSAAVVLTSPDLNEVVRDLESITIGAD
AVELRVDLFKDTSAEFVAAQIAVIRKHADLPIIYTVRTMSQGGKFPDENV
DELKSLLLLGIRLGVAYVDLQLTAPNELIEEISSKKGFTRVIGTYQDING
ELKWNNVEWKNKYNQGVSMNADIVRLVGKANSIQDNLDLENFKKQNTLKP
LIAFNLGSQGKLSQVLNGTFTPISHKLLPNDEGFLTIGELNQTYFDIGGF
TAKKFWVIGSPIEHSRSPNLHNAGYKALNLPYQFGRFEATDVDVVYDNLI
NKPDFGGLAITMPLKLDIMKFATKLSDAAETIGAVNTLIPIEGGYFGDNT
DWVGISNSFIRAGVPPKLSSNGLVVGTGGTSRAAIYALHQMGCAKIYLVN
RTAAKLEELVKSFPKDYNLEIVETEQQADKASKVLLVVSCIPADKPLDGE
VLKKIERILSNGSEQSAGFKPTLLEASYKPRVTPIMKLAEEQYKWKVIPG
VEMLVNQGDRQFKLHTGFIAPYEIIHRALLEE

3D structure

• PDB: 7tbv Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.25: shikimate dehydrogenase (NADP(+)).
  2.5.1.19: 3-phosphoshikimate 1-carboxyvinyltransferase.
  2.7.1.71: shikimate kinase.
  4.2.1.10: 3-dehydroquinate dehydratase.
  4.2.3.4: 3-dehydroquinate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	G1169 L1171 K1198	G300 L302 K329

Gene Ontology

Molecular Function

• GO:0003855 3-dehydroquinate dehydratase activity
• GO:0004764 shikimate 3-dehydrogenase (NADP+) activity

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7tbv, PDBe:7tbv, PDBj:7tbv
• PDBsum: 7tbv
• PubMed: 35512834
• UniProt: Q5AME2|ARO1_CANAL Pentafunctional AROM polypeptide (Gene Name=ARO1)