Structure of PDB 7tao Chain A

Receptor sequence
>7taoA (length=750) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
EKEEAIFRSAEMALVQFYIPQEISRDSAYTLGQLGLVQFRDLNSKVRAFQ
RTFVNEIRRLDNVERQYRYFYSLLKKHDIKLYEGDTDKYLDGSGELYVPP
SGSVIDDYVRNASYLEERLIQMEDATDQIEVQKNDLEQYRFILQSGDEFF
LKVNYVTGVIARDKVATLEQILWRVLRGNLFFKTVEIEQPVYDVKTREYK
HKNAFIVFSHGDLIIKRIRKIAESLDANLYDVDSSNEGRSQQLAKVNKNL
SDLYTVLKTTSTTLESELYAIAKELDSWFQDVTREKAIFEILNKSNYDTN
RKILIAEGWIPRDELATLQARLGEMIARLGIDVPSIIQVLDTNHTPPTFH
RTNKFTAGFQSICDCYGIAQYREINAGLPTIVTFPFMFAIMFGDMGHGFL
MTLAALSLVLNEKKINKMKRGEIFDMAFTGRYIILLMGVFSMYTGFLYND
IFSKTMTIFKSGWKWPDHWKKGESITATSVGTYPIGLDWAWHGTENALLF
SNSYKMKLSILMGFIHMTYSYFFSLANHLYFNSMIDIIGNFIPGLLFMQG
IFGYLSVCIVYKWAVDWVKDGKPAPGLLNMLINMFLSPGTIDDELYPHQA
KVQVFLLLMALVCIPWLLLVKPLHFKFTEDFGDIMIHQVIHTIEFCLNCV
SHTASYLRLWALSLAHAQLSSVLWTMTIQIAFGFRGFVGVFMTVALFAMW
FALTCAVLVLMEGTSAMLHSLRLHWVESMSKFFVGEGLPYEPFAFEYKDM
3D structure
PDB7tao Cryo-EM of the Yeast V O Complex Reveals Distinct Binding Sites for Macrolide V-ATPase Inhibitors.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WEV A I713 V716 I720 I636 V639 I643
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046961 proton-transporting ATPase activity, rotational mechanism
GO:0051117 ATPase binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0006797 polyphosphate metabolic process
GO:0007035 vacuolar acidification
GO:0065003 protein-containing complex assembly
GO:0071469 cellular response to alkaline pH
GO:0071474 cellular hyperosmotic response
GO:1902600 proton transmembrane transport
GO:1903778 protein localization to vacuolar membrane
Cellular Component
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0000324 fungal-type vacuole
GO:0000329 fungal-type vacuole membrane
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0033179 proton-transporting V-type ATPase, V0 domain
GO:0045121 membrane raft

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tao, PDBe:7tao, PDBj:7tao
PDBsum7tao
PubMed35148071
UniProtP32563|VPP1_YEAST V-type proton ATPase subunit a, vacuolar isoform (Gene Name=VPH1)

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