Structure of PDB 7tai Chain A

Receptor sequence
>7taiA (length=424) Species: 9606 (Homo sapiens) [Search protein sequence]
ARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVT
HHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPE
SNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQ
VIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFF
LYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLA
AAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRR
SERYNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQ
STLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILG
KIILFLPCISRKLKRIKKGWEKSQ
3D structure
PDB7tai Structure of STEAP2 in complex with ligands
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.16.1.-
Interaction with ligand
Gene Ontology
Molecular Function
GO:0008823 cupric reductase (NADH) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0052851 ferric-chelate reductase (NADPH) activity
Biological Process
GO:0006826 iron ion transport
GO:0006893 Golgi to plasma membrane transport
GO:0006897 endocytosis
GO:0009725 response to hormone
GO:0015677 copper ion import
GO:0045055 regulated exocytosis
GO:0098705 copper ion import across plasma membrane
GO:0098706 iron ion import across cell outer membrane
GO:0098711 iron ion import across plasma membrane
Cellular Component
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0030140 trans-Golgi network transport vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tai, PDBe:7tai, PDBj:7tai
PDBsum7tai
PubMed37983176
UniProtQ8NFT2|STEA2_HUMAN Metalloreductase STEAP2 (Gene Name=STEAP2)

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