Structure of PDB 7t9v Chain A

Receptor sequence
>7t9vA (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILL
PLDCGVPDNLSMADPNIRFLDKLPQQVYSNSIYELLENGQRAGTCVLEYA
TPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLI
AYQEPADDSSFSLSQEVLRHLRQEEKEEVTV
3D structure
PDB7t9v SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
ChainA
Resolution2.68 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D205 E316 D53 E154
BS02 GC0 A L159 S162 Y167 Y240 S241 L7 S10 Y15 Y78 S79
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:7t9v, PDBe:7t9v, PDBj:7t9v
PDBsum7t9v
PubMed35595822
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

[Back to BioLiP]