Structure of PDB 7t9u Chain A

Receptor sequence
>7t9uA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILL
PLDCGVPDNLSMADPNIRFLDKLPQQVYSNSIYELLENGQRAGTCVLEYA
TPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLI
AYQEPAFSLSQEVLRHLRQEEKEEVTV
3D structure
PDB7t9u SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
ChainA
Resolution2.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D205 E316 D53 E154
BS02 GD2 A S162 Y163 Y167 Y240 S241 P264 S10 Y11 Y15 Y78 S79 P102
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:7t9u, PDBe:7t9u, PDBj:7t9u
PDBsum7t9u
PubMed35595822
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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